NR AGZO
AU Lane,K.L.; Brown,P.; Howell,D.N.; Crain,B.J.; Hulette,C.M.; Burger,P.C.; DeArmond,S.J.
TI Creutzfeldt-Jakob disease in a pregnant woman with an implanted dura mater graft
QU Neurosurgery 1994 Apr; 34(4): 737-9; discussion 739-40
PT journal article
AB A 28-year-old woman with prior neurosurgery involving the placement of a cadaveric dural graft developed a rapidly progressive neurodegenerative disorder with prominent cerebellar dysfunction that was proven at autopsy to be Creutzfeldt-Jakob disease. She represents the second American to develop Creutzfeldt-Jakob disease in association with a dural graft. The unusual features of the case include the patient's initial clinical presentation with cerebellar ataxia in the absence of dementia, the widespread presence of kuru-type amyloid plaques on a histological examination of the brain, the development of clinical symptoms during pregnancy, and the subsequent delivery of a child who remains healthy at the age of 3 years.
IN Eine 28-jährige Amerikanerin wurde nach einer Gehirnhauttransplantation (Lyodura) von einer rasch fortschreitenden Creutzfeldt-Jakob-Krankheit befallen. Sie brachte aber noch ein Kind zur Welt, das nach 3 Jahren noch immer gesund zu sein scheint. Auffallend ist, dass diese Patientin zunächst Kleinhirn-bedingte Bewegungsstörungen ohne Demenz und am Ende weit verbreitet Kuru-Plaques zeigte.
MH Adult; Arnold-Chiari Malformation/pathology/*surgery; Atrophy; Brain/pathology; Case Report; Collagen/*adverse effects; Creutzfeldt-Jakob Syndrome/diagnosis/pathology/*transmission; Female; Human; Infant, Newborn; Male; Nerve Degeneration/physiology; Neurologic Examination; Postoperative Complications/*diagnosis/pathology; Pregnancy; Pregnancy Complications, Infectious/*diagnosis/pathology
AD Department of Pathology, Duke University Medical Center, Durham, North Carolina.
SP englisch
PO USA