NR AGZY
AU Lansbury,P.T.Jr.
TI Yeast prions: bungee cord domains' balancing act.
QU Current Biology 1999 Nov 18; 9(22): R845-7
PT journal article; review; review, tutorial
AB The yeast prion-like protein Sup35 has repeats responsible for the reversible induction of an altered, but advantageous phenotype. The expansion of similar repeat domains in several mammalian proteins is associated with neurodegenerative disease - so why are these 'bungee cord' domains conserved?
ZR 17
MH Fungal Proteins/*chemistry/physiology; Human; Mutagenesis, Insertional; Nerve Tissue Proteins/genetics/metabolism; Neurodegenerative Diseases/genetics/metabolism; Nuclear Proteins/genetics/metabolism; Peptide Fragments/physiology; Peptides/metabolism; Phenotype; PrPc Proteins/chemistry/physiology; PrPsc Proteins/chemistry; Prion Diseases/genetics/metabolism; Prions/*chemistry/physiology; Protein Conformation; Protein Folding; Protein Structure, Tertiary; Recombinant Fusion Proteins/physiology; Repetitive Sequences, Amino Acid; Saccharomyces cerevisiae/chemistry/*genetics; Structure-Activity Relationship
AD Department of Neurology, Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, 02115, USA. lansbury@cnd.bwh.harvard.edu
SP englisch
PO England