NR AHBG
AU Lasmezas,C.I.; Fournier,J.G.; Nouvel,V.; Boe,H.; Marce,D.; Lamoury,F.; Kopp,N.; Hauw,J.J.; Ironside,J.; Bruce,M.; Dormont,D.; Deslys,J.P.
TI Adaptation of the bovine spongiform encephalopathy agent to primates and comparison with Creutzfeldt-Jakob disease: implications for human health.
QU Proceedings of the National Academy of Sciences of the United States of America 2001 Mar 27; 98(7): 4142-7
IA http://www.pnas.org/cgi/content/full/98/7/4142
PT journal article
AB There is substantial scientific evidence to support the notion that bovine spongiform encephalopathy (BSE) has contaminated human beings, causing variant Creutzfeldt-Jakob disease (vCJD). This disease has raised concerns about the possibility of an iatrogenic secondary transmission to humans, because the biological properties of the primate-adapted BSE agent are unknown. We show that (i) BSE can be transmitted from primate to primate by intravenous route in 25 months, and (ii) an iatrogenic transmission of vCJD to humans could be readily recognized pathologically, whether it occurs by the central or peripheral route. Strain typing in mice demonstrates that the BSE agent adapts to macaques in the same way as it does to humans and confirms that the BSE agent is responsible for vCJD not only in the United Kingdom but also in France. The agent responsible for French iatrogenic growth hormone-linked CJD taken as a control is very different from vCJD but is similar to that found in one case of sporadic CJD and one sheep scrapie isolate. These data will be key in identifying the origin of human cases of prion disease, including accidental vCJD transmission, and could provide bases for vCJD risk assessment.
MH Adaptation, Biological; Animal; Cattle; Comparative Study; Creutzfeldt-Jakob Syndrome/physiopathology/*transmission; Disease Models, Animal; Encephalopathy, Bovine Spongiform/physiopathology/*transmission; Female; Human; Immunohistochemistry; Mice; Mice, Inbred C57BL; Phenotype; Primate Diseases/transmission; Primates; Prions/*analysis; Scrapie/physiopathology; Support, Non-U.S. Gov't
AD lasmezas@cea.fr Commissariat a l'Energie Atomique, Service de Neurovirologie, Direction des Sciences du Vivant/Departement de Recherche Medicale, Centre de Recherches du Service de Sante des Armees 60-68, Avenue du General Leclerc, BP 6, 92 265 Fontenay-aux-Roses Cedex, France; Hopital Neurologique Pierre Wertheimer, 59, Boulevard Pinel, 69003 Lyon, France; Laboratoire de Neuropathologie, Hopital de la Salpetriere, 83, Boulevard de l'Hopital, 75013 Paris, France; Creutzfeldt-Jakob Disease Surveillance Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, United Kingdom; and Institute for Animal Health, Neuropathogenesis Unit, West Mains Road, Edinburgh EH9 3JF, United Kingdom.
SP englisch
PO USA