NR AHCF
AU Lazarini,F.; Deslys,J.P.; Dormont,D.
TI Variations in prion protein and glial fibrillary acidic protein mRNAs in the brain of scrapie-infected newborn mouse
QU Journal of General Virology 1992 Jul; 73(7): 1645-8
PT journal article
AB To begin to understand the molecular basis of cases of Creutzfeldt-Jakob disease recently described in young children, the expression of prion protein and glial fibrillary acidic protein (GFAP) mRNAs was investigated during the development of the brain of scrapie-infected newborn mice. Changes in the time course of expression were identified by Northern blot quantification between days 1 and 172. Although scrapie-infected and control animals showed no detectable changes in brain development (first 56 days of life), GFAP mRNAs were found to increase significantly as early as day 84. A 10-fold increase in the level of GFAP mRNA was observed in brain between day 112 and death (day 172).
MH Animal; Animals, Newborn; Brain/*microbiology; Brain Chemistry; Gene Expression Regulation, Viral; Glial Fibrillary Acidic Protein/*genetics; Mice; Mice, Inbred C57BL; PrPsc Proteins; Prions/*genetics; RNA, Messenger/*analysis; Scrapie/*metabolism
AD Laboratoire de Neuropathologie Experimentale, CRSSA, DSV/DPTE, Commissariat a l'Energie Atomique, Fontenay aux Roses, France.
SP englisch
PO England