NR AHCN
AU Le,Y.; Oppenheim,J.J.; Wang,J.M.
TI Pleiotropic roles of formyl peptide receptors
QU Cytokine and Growth Factor Reviews 2001 Mar; 12(1): 91-105
PT journal article; review; review, tutorial
AB FPR and FPRL1 belong to the seven-transmembrane, G protein-coupled chemoattractant receptor superfamily. Because of their capacity to interact with bacterial chemotactic formylated peptides, these receptors are thought to play a role in host defense against microbial infection. Recently, a variety of novel agonists have been identified for these receptors, including several host-derived endogenous molecules that are involved in proinflammatory responses. Most notably is the use of FPRL1 by at least three amyloidogenic protein and peptide ligands, the serum amyloid A (SAA), the 42 amino acid form of beta amyloid (Abeta(42)), and the prion peptide PrP106-126, to chemoattract and activate human phagocytic leukocytes. These new findings have greatly expanded the functional scope of the formyl peptide receptors and call for more in-depth investigation of the role of these receptors in pathophysiological conditions.
ZR 147
MH Amyloidosis/*immunology/physiopathology; Animal; Annexin I/metabolism; HIV Infections/*immunology/physiopathology; Human; Ligands; Neurodegenerative Diseases/*immunology/physiopathology; Phosphorylation; Receptors, Immunologic/agonists/antagonists & inhibitors/*physiology; Receptors, Peptide/agonists/antagonists & inhibitors/*physiology; *Signal Transduction; Support, U.S. Gov't, P.H.S.
AD Laboratory of Molecular Immunoregulation, Division of Basic Sciences, National Cancer Institute at Frederick, Frederick, MD 21702, USA. ley@mail.ncifcrf.gov
SP englisch
PO England