NR AHEO
AU Lemstra,A.W.; van Meegen,M.T.; Baas,F.; van Gool,W.A.
TI [Clinical algorithm for cerebrospinal fluid test of 14-3-3 protein in diagnosis of Creutzfeldt-Jakob disease]
OT Een klinisch algoritme voor het gebruik van de 14-3-3-liquortest bij de diagnostiek van de ziekte van Creutzfeldt-Jakob
QU Nederlands Tijdschrift voor Geneeskunde 2001 Jul 28; 145(30): 1467-71
PT evaluation studies; journal article
AB OBJECTIVE: To study whether an algorithm that includes additional diagnostic information could increase the specificity of the 14-3-3 protein testing in patients suspected to suffer from Creutzfeldt-Jakob disease (CJD). DESIGN: The development of a diagnostic algorithm. METHOD: The 14-3-3 protein was tested in the cerebrospinal fluid from 69 consecutive patients suspected of having CJD. On the basis of a former study and literature research, a diagnostic algorithm was constructed, which restricted the indication for performing the 14-3-3 protein test. RESULTS: By taking into consideration the findings of neuroimaging and routine cerebrospinal fluid examination prior to 14-3-3 testing, the specificity increased to 97% (95%-CI: 85.5-99.9) thus changing the prior probability of having CJD of 35% to a posterior probability of 75-100%, in the case of a positive test result. CONCLUSION: Determining the presence of 14-3-3 protein is a highly sensitive and specific marker for sporadic CJD when used in combination with imaging and cerebrospinal fluid examination.
MH Adolescent; Adult; Aged; Aged, 80 and over; Algorithms; Biological Markers/cerebrospinal fluid; Child; Creutzfeldt-Jakob Syndrome/*cerebrospinal fluid/*diagnosis; Diagnosis, Differential; English Abstract; Female; Human; Immunoblotting; Male; Middle Age; Sensitivity and Specificity; Tyrosine 3-Monooxygenase/*cerebrospinal fluid
AD Afd. Neurologie, Academisch Medisch Centrum, Postbus 22700, 1100 DE Amsterdam. a.w.lemstra@amc.uva.nl
SP niederländisch
PO Niederlande