NR AHEY
AU Leontides,S.; Psychas,V.; Argyroudis,S.; Giannati-Stefanou,A.; Paschaleri-Papadopoulou,E.; Manousis,T.; Sklaviadis,T.K.
TI A survey of more than 11 years of neurologic diseases of ruminants with special reference to transmissible spongiform encephalopathies (TSEs) in Greece
QU Journal of Veterinary Medicine. Series B, Infectious Diseases and Veterinary Public Health 2000 May; 47(4): 303-9
PT journal article
AB The first cases of scrapie were detected in Greece in a flock of sheep in October 1986. All the animals of the affected flock and all sheep in two flocks that were in contact were killed and buried. A systematic investigation of all available cases with signs indicating a neurological disease started in sheep and goats in late 1986, as well as in cattle in 1989. The investigation was based on clinical examination, necropsy or macroscopical examination of the brain and viscera, and histological examination of the brain in all animals except those with coenurosis. Histological examinations of specimens from the spinal cord and other tissues, and if considered necessary bacteriological, toxicological and serological examinations were also carried out. In October 1997, scrapie was diagnosed in sheep of a second flock (a mixed flock of sheep and goats), grazing in a pasture close to the place where scrapie was initially detected. All animals of the second flock were also killed and buried. Diagnosis in the first flock was based on clinical signs and histological lesions, and in the second immunoblotting was also used. Distinctive lesions of scrapie were found in the brain and/or the spinal cord of eight sheep with clinical signs from the two flocks. The lesions were revealed in the brain stem and/or in the cervical spinal cord, and tended to be symmetrical. In one sheep, severe lesions in the cortex of cerebral hemispheres and of the cerebellum were also found. In the brain of two sheep from the second flock the pathological isoform of PrP protein was detected. Despite the eradication scheme applied, scrapie in sheep reappeared after 11 years in a place close to where it occurred initially. This may indicate that the effectiveness of the eradication scheme implemented was not adequate and additional approaches may be needed.
IN Die ersten 6 als solche erkannten Scrapie-Fälle wurden in einer griechischen Schafherde im Oktober 1986 aufgrund von klinischen Symptomen und histopathologischen Läsionen diagnostiziert. Alle Schafe in dieser und zwei Kontaktherden wurden getötet und vergraben. Im Oktober 1997 trat Scrapie in einer Herde von Schafen und Ziegen auf, die in der Nähe der ersten Scrapie-Herde graste. Diesmal wurden zwei Scrapie-Diagnosen auch per Immunoblot abgesichert, aber wieder wurden alle Tiere der Herde getötet und einfach vergraben.
MH Animal; Brain/pathology; Cattle; Cattle Diseases/epidemiology; Central Nervous System Diseases/epidemiology/pathology/*veterinary; Female; Goat Diseases/*epidemiology/pathology; Goats; Greece/epidemiology; Male; Prion Diseases/epidemiology/pathology/*veterinary; Scrapie/epidemiology/pathology; Sheep; Sheep Diseases/*epidemiology/pathology; Spinal Cord/pathology
AD Laboratory of Pathology, Faculty of Veterinary Medicine, Aristotle University, Thessaloniki, Greece.
SP englisch
PO Deutschland