NR AHGU
AU Liberski,P.P.; Giraud,P.; Kopp,N.
TI Ultrastructural pathology of Creutzfeldt-Jakob disease and fatal familial insomnia
QU Folia Neuropathologica 2000; 38(4): 171-3
PT journal article
AB In this study we examined well fixed brain biopsies of 9 sporadic CJD, 9 iatrogenic CJD cases, 2 hereditary CJD (Gly200Lys and Val203Iso), a case of vCJD and a case of fatal familial insomnia (FFI) from a new French family collected over the years at the Service de Neuropathologie, Hopital Neurologique, Lyon, France. Tubulovesicular structures (TVS) were found in every case including FFI and nvCJD. Thus, TVS, as we suggested previously are important pathologic structure which significance should be more extensively studied.
MH Amino Acid Substitution; Amyloid/analysis/genetics; Biopsy; Cerebral Cortex/chemistry/*ultrastructure; Codon/genetics; Creutzfeldt-Jakob Syndrome/*pathology/transmission; France; Human; Human Growth Hormone/adverse effects; Iatrogenic Disease; Microscopy, Electron; Point Mutation; Prion Diseases/genetics/*pathology; Protein Precursors/analysis/genetics; Support, Non-U.S. Gov't; Vacuoles/ultrastructure
AD Department of Molecular Biology, Chair of Oncology, Medical Academy Lodz, Poland. ppliber@psk2.am.lodz.pl
SP englisch
PO Polen