NR AHGW
AU Liberski,P.P.
TI Bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease: a risk analysis.
QU Folia Neuropathologica 2000; 38(4): 143-50
PT journal article; review; review, tutorial
AB There is doubt that variant Creutzfeldt-Jakob disease (vCJD) resulted from bovine spongiform encephalopathy (BSE) transmission from cattle to human. What is uncertain is the total number of vCJD cases (currently about 80). In this review I covered recent data on the vCJD and BSE epidemic, the mode of BSE spreading to humans and, finally, the data on the PRNP analogue - the doppel gene (PRND).
ZR 31
MH Adolescent; Adult; Aged; Animal; Animal Feed/adverse effects; Cattle; Child; Creutzfeldt-Jakob Syndrome/*epidemiology/prevention & control/transmission; Disease Outbreaks; Disease Transmission, Vertical; Encephalopathy, Bovine Spongiform/*epidemiology/transmission; Europe/epidemiology; Female; Goats; Great Britain/epidemiology; Human; Incidence; Infant; Ireland/epidemiology; Male; Meat/adverse effects; Mice; Middle Age; Mutagenesis, Insertional; Mutation; Open Reading Frames/genetics; Organ Specificity; Poland; Pregnancy; Pregnancy Complications, Infectious/etiology; Prions/classification/genetics/isolation & purification/pathogenicity; Protein Isoforms/chemistry; Scrapie/etiology; Sheep; Species Specificity; Support, Non-U.S. Gov't
AD Department of Molecular Biology, Chair of Oncology, Medical Academy Lodz, Poland. ppliber@psk2.am.lodz.pl
SP englisch
PO Polen