NR AHHH
AU Liberski,P.P.
TI How do neurons degenerate in transmissible spongiform encephalopathies?
QU Molecular and Chemical Neuropathology 1996 May-Aug; 28(1-3): 245-9
PT journal article; review; review, tutorial
AB Neuroaxonal dystrophy is a feature of neuronal degeneration encountered in all subacute spongiform virus encephalopathies including scrapie and Creutzfeldt-Jakob disease (CJD). By immunohistochemical techniques, the accumulation of 200 kDa neurofilament protein was demonstrated in affected neurites in human CJD. These neurites exhibited the ultrastructural features of dystrophic neurites encountered in other neurodegenerative disorders, particularly Alzheimer's disease. These findings support the hypothesis that impairment of slow axoplasmic transport is a common pathogenetic mechanism for CJD and many other neurodegenerative conditions.
IN In Neuriten eines Creutzfeldt-Jakob-Patienten wurde die Akkumulaton eines 200 kDa-Neurofilamentproteins beobachtet. Die Neuriten zeigten dystrophe Veränderungen, wie sie auch bei anderen neurogenerativen Krankheiten, insbesondere bei Alzheimer gefunden werden. Der Autor schließt daraus, dass eine Behinderung des langsamen Plasmatransportes in Axonen ein allgemeiner pathologischer Mechanismus bei der Creutzfeldt-Jakob-Krankheit und vielen anderen neurogenerativen Krankheiten sei.
ZR 10
MH Alzheimer Disease/pathology; Animal; Comparative Study; Creutzfeldt-Jakob Syndrome/pathology; Human; Immunohistochemistry; Neurites/pathology/ultrastructure; Neurofilament Proteins/analysis; Neurons/*pathology; Prion Diseases/*pathology/transmission; Scrapie/pathology; Support, Non-U.S. Gov't
AD Laboratory of Election Microscopy and Neuropathology, Medical Academy Lodz, Poland.
SP englisch
PO USA