NR AHIE
AU Liberski,P.P.; Yanagihara,R.; Gibbs,C.J.Jr.; Gajdusek,D.C.
TI Neuronal autophagic vacuoles in experimental scrapie and Creutzfeldt-Jakob disease
QU Acta Neuropathologica 1992; 83(2): 134-9
PT journal article
AB We report the presence of autophagic vacuoles (AV) in neuronal perikarya and neuronal processes of rodents with experimental scrapie and Creutzfeldt-Jakob disease. AV were composed of sequestrated cytoplasmic areas containing ribosomes and occasionally mitochondria and small secondary vacuoles. The formation of AV may contribute to neuronal degeneration and ultimately to neuronal loss.
MH Animal; Case Report; Creutzfeldt-Jakob Syndrome/*pathology; Cytoplasm/ultrastructure; Human; Male; Mice; Microscopy, Electron; Middle Age; Nerve Degeneration/physiology; Neurons/*ultrastructure; Ribosomes/ultrastructure; Scrapie/*pathology; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S.
AD Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.
SP englisch
PO Deutschland