NR AHIF
AU Liberski,P.P.; Mirecka,B.; Alwasiak,J.; Yanagihara,R.; Gajdusek,D.C.
TI Expression of tumor necrosis factor-alpha cachectin in primary brain tumors of astrocytic lineage
QU Neuropatologia Polska 1992; 30(1): 35-42
PT journal article
AB The tumor necrosis factor alpha (TNF-alpha) is a cytokine released within central nervous system from activated astrocytes and macrophages and involved in several pathologic processes including AIDS-myelopathy, multiple sclerosis and myelin dilatation in panencephalic type of Creutzfeldt-Jakob disease. We studied the expression of the TNF-alpha in brain tumors. Only tumors of astrocytic lineage like astrocytomas and glioblastomas, or tumors of mixed lineage as oligo-astrocytomas and multipotential primitive neuroectodermal tumors (PNET) expressed TNF-alpha-like immunoreactivity. We conclude that this lymphokine is expressed in neoplastic astrocytes. We postulate that TNF-alpha may participate in neoplastic transformation of astrocytes via cascade of interactions with receptor for TNF-alpha.
MH Astrocytoma/*metabolism; Brain Neoplasms/*metabolism; Glial Fibrillary Acidic Protein/biosynthesis; Human; Support, Non-U.S. Gov't; Tumor Cells, Cultured; Tumor Necrosis Factor/*biosynthesis
AD Dept. Oncology, School of Medicine, Lodz, Poland.
SP englisch
PO Polen