NR AHJY
AU Lieberburg,I.
TI Developmental expression and regional distribution of the scrapie-associated protein mRNA in the rat central nervous system
QU Brain Research 1987 Aug 11; 417(2): 363-6
PT journal article
AB The scrapie associated protein (SAP) has been shown to be a normal brain protein of yet undefined function. This study demonstrates that rat brain SAP mRNA levels undergo a transcriptionally dependent increase during normal development. The interregional variation in the adult rat central nervous system (CNS) is roughly 10 fold, with highest levels in the basal ganglion/thalamus and lowest levels in the spinal cord.
MH Animal; Central Nervous System/embryology/growth & development/*metabolism; *Gene Expression Regulation; Male; Nerve Tissue Proteins/*genetics/metabolism; Nucleic Acid Hybridization; PrP 27-30 Protein; RNA/diagnostic use; RNA, Complementary; RNA, Messenger/*metabolism/physiology; Rats; Rats, Inbred Strains; Subcellular Fractions; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S.; Transcription, Genetic
AD Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461.
SP englisch
PO Niederlande