NR AHNA
AU Lones,M.A.; Kirov,I.; Said,J.W.; Shintaku,I.P.; Neudorf,S.
TI Post-transplant lymphoproliferative disorder after autologous peripheral stem cell transplantation in a pediatric patient
QU Bone Marrow Transplantation 2000 Nov; 26(9): 1021-4
PT journal article; review; review of reported cases
AB Post-transplant lymphoproliferative disorder (PTLD) is a complication of allogeneic bone marrow transplantation (BMT). Rare cases of PTLD after autologous BMT have been reported only in adults. This case report is the first to describe PTLD in a pediatric patient after autologous peripheral stem cell transplantation (PSCT). This 2-year-old male with stage IV neuroblastoma underwent autologous PSCT. The post-PSCT course was complicated by fever with hematochezia and a lung mass. On day 94 post PSCT, colonoscopy revealed an ulcer due to a PTLD, monomorphic type, B cell phenotype, associated with Epstein-Barr virus. Fine needle aspiration identified the lung mass as neuroblastoma. PTLD can occur in pediatric autologous PSCT recipients, and may occur more frequently in autologous grafts manipulated by T cell depletion or CD34+ cell selection.
ZR 17
MH Adrenal Gland Neoplasms/drug therapy/surgery/*therapy; Adrenalectomy; Antineoplastic Combined Chemotherapy Protocols/therapeutic use; Case Report; Child, Preschool; Cisplatin/administration & dosage; Colonic Diseases/etiology/virology; Combined Modality Therapy; Cyclophosphamide/administration & dosage; Cytomegalovirus Infections/etiology; Doxorubicin/administration & dosage; Duodenal Ulcer/etiology/virology; Epstein-Barr Virus Infections/complications; Etoposide/administration & dosage; Gastrointestinal Hemorrhage/etiology; *Hematopoietic Stem Cell Transplantation; Human; Immunocompromised Host; Immunosuppressive Agents/*adverse effects; Lung Neoplasms/secondary; Lymphatic Metastasis; Lymphoma, Large-Cell/*etiology/pathology/virology; Male; Neuroblastoma/drug therapy/secondary/surgery/*therapy; Orbital Neoplasms/secondary; Prion Diseases; Transplantation Conditioning/*adverse effects; Transplantation, Autologous; Ulcer/etiology/virology; Vincristine/administration & dosage
AD Pathology Department, Children's Hospital of Orange County/St Joseph Hospital, Orange, CA 92863-5600, USA
SP englisch
PO England