NR AHQJ
AU Macario,M.E.; Moura-Neto,V.; Vaisman,M.; Araujo,H.M.; Buescu,A.; Cordeiro,J.G.; Chagas,C.
TI Abnormal proteins in the cerebrospinal fluid of a patient with Creutzfeldt-Jakob disease following administration of human pituitary growth hormone
QU Brazilian Journal of Medical and Biological Research 1992; 25(11): 1127-30
PT journal article
AB A Brazilian case of Creutzfeldt-Jakob disease in a hypopituitary patient who had received cadaver-derived human pituitary growth hormone between 1968 and 1977 is reported. The clinical diagnosis was confirmed during his lifetime by the demonstration of two abnormal 30-kDa proteins in the cerebrospinal fluid by two-dimensional gel electrophoresis. These proteins, characteristic of Creutzfeldt-Jakob disease, present isoelectric points of 5.1 and 5.2. Furthermore, both proteins migrate as doublets, each one displaying a molecular weight variant of about 29-kDa. This is one of 16 cases of the disease associated to therapy with cadaver-derived human growth hormone and one of the few examples among such cases of confirmation of the clinical diagnosis by biochemical characterization of abnormal proteins in the cerebrospinal fluid.
MH Adult; Brazil; Case Report; Cerebrospinal Fluid Proteins/cerebrospinal fluid/*drug effects; Chronic Disease; Creutzfeldt-Jakob Syndrome/*cerebrospinal fluid/diagnosis/*drug; therapy/etiology; Electrophoresis, Gel, Two-Dimensional; Growth Hormone/adverse effects/*therapeutic use; Human; Hypopituitarism/cerebrospinal fluid/complications/drug therapy; Male; Molecular Weight; Support, Non-U.S. Gov't
AD Servico de Endocrinologia, Hospital Universitario Clementino Fraga Filho, Rio de Janeiro, Brasil.
SP englisch
PO Brasilien