NR AHQL
AU Macchi,G.; Rossi,G.; Abbamondi,A.L.; Giaccone,G.; Mancia,D.; Tagliavini,F.; Bugiani,O.
TI Diffuse thalamic degeneration in fatal familial insomnia. A morphometric study.
QU Brain Research 1997 Oct 10; 771(1): 154-8
PT journal article
AB A morphometric investigation disclosed most thalamic nuclei severely degenerated in two patients with fatal familial insomnia. Associative and motor nuclei lost 90% neurons, and limbic-paralimbic, intralaminar and reticular nuclei lost 60%. These findings point to the disorganization of most thalamic circuits as a condition necessary for the sleep-wake rhythm being affected.
MH Adult; Asparagine; Aspartic Acid; Case Report; Codon; Creutzfeldt-Jakob Syndrome/pathology; Fatal Outcome; Female; Human; Male; Middle Age; Nerve Degeneration/*genetics/*pathology; Neurons/pathology; Point Mutation; Prions/*genetics; Reference Values; Sleep Initiation and Maintenance Disorders/*genetics/*pathology; Support, Non-U.S. Gov't; Thalamic Nuclei/*pathology
AD Istituto Neurologico Carlo Besta, Milan, Italy.
SP englisch
PO Niederlande