NR AHUA
AU Mansuy,I.M.; Bujard,H.
TI Tetracycline-regulated gene expression in the brain
QU Current Opinion in Neurobiology 2000 Oct; 10(5): 593-6
PT journal article; review; review, tutorial
AB The possibility of regulating individual gene activities in the mouse brain via the tetracycline-controlled transcriptional activation systems has sparked the development of novel mouse models aimed at elucidating the molecular mechanisms of brain disorders such as Huntington's, prion and Parkinson's diseases. In the past year, novel experimental strategies and methodological advances have emerged, contributing to the resolution of some of the initial limitations of these regulatory systems.
ZR 26
MH Animal; Brain Chemistry/*drug effects/*genetics; Gene Expression/*drug effects; Human; Nerve Tissue Proteins/biosynthesis; Neurodegenerative Diseases/genetics/metabolism; Protein Synthesis Inhibitors/*pharmacology; Support, Non-U.S. Gov't; Tetracycline/*pharmacology
AD Swiss Federal Institute of Technology, Institute of Cell Biology, Eidgenössische Technische Hochschule Hönggerberg, CH-8093, Zürich, Switzerland.
SP englisch
PO England