NR AHUD
AU Manuelidis,E.E.; Rorke,L.B.
TI Transmission of Alpers' disease (chronic progressive encephalopathy) produces experimental Creutzfeldt-Jakob disease in hamsters
QU Neurology 1989 May; 39(5): 615-21
PT journal article
AB We successfully and serially transmitted to outbred and inbred strains of hamsters the brain tissue of a 2 1/2-year-old girl with a chronic progressive encephalopathy (Alpers' disease) characterized postmortem as a spongiform encephalopathy. In all hamster strains we produced a spongiform encephalopathy. The light and ultrastructural changes in the brain of hamsters, as well as the clinical signs of experimental disease, are identical to those obtained in transmission experiments of human Creutzfeldt-Jakob disease (CJD). CJD infection may be more widespread than previously recognized and can be manifested in infancy.
IN Gehirnmaterial eines 2,5 Jahre alten, anscheinend am Alpers Disease gestorbenen Mädchens mit einer per Autopsie bestätigten spongiformen Enzephalopathie wurde erfolgreich auf Hamster übertragen und erzeugte wiederum auf Hamster übertragbare spongiforme Enzephalopathien, welche klinisch nicht von durch die Übertragung von Creutzfeldt-Jakob-Material erzeugten Fällen unterscheidbar waren.
MH Animal; Brain/pathology/ultrastructure; Brain Diseases/pathology/*transmission; Case Report; Child, Preschool; Chronic Disease; Creutzfeldt-Jakob Syndrome/pathology/*transmission; Female; Guinea Pigs; Hamsters; Human; Mesocricetus; Microscopy, Electron; Nerve Tissue/transplantation; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S.; *Zoonoses
AD Section of Neuropathology, Yale University School of Medicine, New Haven, CT 06510.
SP englisch
PO USA