NR AHUF
AU Manuelidis,E.E.; de Figueiredo,J.M.; Kim,J.H.; Fritch,W.W.; Manuelidis,L.
TI Transmission studies from blood of Alzheimer disease patients and healthy relatives
QU Proceedings of the National Academy of Sciences of the United States of America 1988 Jul; 85(13): 4898-901
PT journal article
AB The etiology of Alzheimer disease (AD) is unknown. To investigate the transmissibility of AD, the buffy coat of the blood from 11 relatives of AD patients, including 2 with suspicious or early signs of AD, was inoculated intracerebrally into hamsters. In these pilot experiments, 5 individuals produced histologically documented spongiform encephalopathy on primary passage in recipient hamsters. Material from 3 of these positives was serially transmitted in a second passage. The histological alterations observed in the brains of positive hamsters were similar to those seen in experimental Creutzfeldt-Jakob disease (CJD). These transmission results raise the intriguing possibility that CJD-like agents may be involved in at least some forms of AD.
IN Buffy coat von 11 Verwandten von Alzheimer-Patienten wurde Hamstern intrazerebral inokuliert. Zwei der Spender zeigten möglicherweise frühe Alzheimer-Symptome. Empfängerhamster von 5 Spendern entwickelten spongiforme Enzephalopathien. Material von 3 dieser Hamster übertrug die Krankheit auf weitere Hamster. Die Gehirne der erkrankten Hamster glichen histologisch denen von mit Creutzfeldt-Jakob-Material infizierten.
MH Adult; Alzheimer Disease/blood/genetics/*transmission; Animal; Brain/pathology; Brain Diseases/*etiology/pathology; Comparative Study; Female; Hamsters; Human; Injections; Male; Mesocricetus; Middle Age; Pilot Projects; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S.
AD Section of Neuropathology, Yale University, School of Medicine, New Haven, CT 06510.
SP englisch
PO USA