NR AHUR
AU Manuelidis,E.E.
TI Transmission of Creutzfeldt-Jakob disease from man to the guinea pig
QU Science 1975 Nov 7; 190(4214): 571-2
PT journal article
AB Intracerebral and intraperitoneal inoculation of two guinea pigs with biopsy material from a patient with Creutzfeldt-Jakob disease produced a similar fatal encephalopathy characterized by status spongiosus 422 and 512 days after inoculation. Serial transmission of this disease from guinea pig to guinea pig was achieved in subsequent passages.
IN Der Autor übertrug anscheinend erstmals mit Biopsie-Material die Creutzfeldt-Jakob-Krankheit auf Meerschweinchen, mit denen wiederum andere Meerschweinchen infiziert wurden.
MH Animal; Brain/pathology; *Creutzfeldt-Jakob Syndrome/pathology; *Disease Models, Animal; Female; *Guinea Pigs; Human; Middle Age; Support, U.S. Gov't, P.H.S.
SP englisch
PO USA