NR AHWF
AU Markovits,P.; Dormont,D.; Maunoury,R.; Delamarche,C.; Delpech,A.; Dianoux,L.; Latarjet,R.
TI [In vitro modification of the morphology and the growth of cells infected with scrapie (author's trans)]
OT Modifications in vitro de la morphologie et de la croissance de cellules infectees par l'agent scrapie
QU Comptes Rendus des Seances de l'Academie des Sciences. Serie III, Sciences de la Vie 1982 Feb 15; 294(7): 305-12
PT journal article
AB Seven cell lines originated either in brains or in neuroblastomas of Mice, were infected with Scrapie. After 12 to 16 in vitro passages, 6 lines out of 7 showed changes of their morphology, and of their growth, resembling those occurring in the course of a malignant transformation. The Scrapie infected cells acquired the capacity to form 2 to 4 times more colonies in liquid medium than the controls, and to develop large tridimensional colonies in semisolid medium. The role of Scrapie in these changes is discussed.
MH Animal; Brain/*microbiology; Brain Neoplasms/*microbiology/pathology; Cell Line; *Cell Transformation, Neoplastic; *Cell Transformation, Viral; English Abstract; Mice; Neoplasms, Experimental/microbiology/pathology; Neuroblastoma/*microbiology/pathology; Prions/*genetics
SP französisch
PO Frankreich