NR AHYB
AU Martinez-Lage,J.F.; Sola,J.; Poza,M.; Esteban,J.A.
TI Pediatric Creutzfeldt-Jakob disease: probable transmission by a dural graft.
QU Childs Nervous System 1993 Jul; 9(4): 239-42
PT journal article; review; review of reported cases
AB A 10-year-old boy underwent a posterior fossa craniectomy for removal of a grade 2 cerebellar astrocytoma. Dural closure was achieved by the placement of a dural graft. Eight years later the patient developed dementia and myoclonus. Electroencephalography demonstrated generalized slow activity that evolved into a pattern of periodic triphasic waves. Computed tomography scan and magnetic resonance imaging were unremarkable. Brain biopsy confirmed spongiform encephalopathy of the Creutzfeldt-Jakob type. In the light of previous reports of four similar occurrences, and of our own experience with two further cases of this disease, we believe that the cadaveric dura was the source of transmission of Creutzfeldt-Jakob disease in our patient. The authors remark the importance of the awareness of this late complication of dural substitutes, both for the diagnosis of possible future cases and for taking preventive measures to stop the spread of the disease.
IN Nach Entfernung eines Tumors in der hinteren Schädelgrube erhielt ein 10-jähriger Junge ein dura mater Implantat. 8 Jahre danach entwickelte er eine Demenz und Myoklonien. Das EEG zeigte zunächst generell langsame Aktivitäten und später das typische Muster periodischer triphasischer Wellen. Computertomogramm und NMR waren unauffällig. Eine Gehirnbiopsie lieferte die Diagnose CJK. Die Autoren warnen vor dieser Spätfolge einer Dura mater Transplantation.
ZR 22
MH Astrocytoma/*surgery; Biopsy; Cadaver; Case Report; Cerebellar Neoplasms/*surgery; Child; *Collagen; Creutzfeldt-Jakob Syndrome/diagnosis/pathology/*transmission; Dura Mater/*transplantation; Electroencephalography; Frontal Lobe/pathology; Human; Magnetic Resonance Imaging; Male; Postoperative Complications/*diagnosis/pathology; Tomography, X-Ray Computed
AD Regional Service of Neurosurgery, University Hospital, Virgen de Arrixaca, Murcia, Spain.
SP englisch
PO Deutschland