NR AHYQ
AU Marzewski,D.J.; Towfighi,J.; Harrington,M.G.; Merril,C.R.; Brown,P.
TI Creutzfeldt-Jakob disease following pituitary-derived human growth hormone therapy: a new American case.
QU Neurology 1988 Jul; 38(7): 1131-3
PT journal article
AB A fourth histologically-confirmed American case of Creutzfeldt-Jakob disease (CJD) related to human growth hormone (hGH) therapy is reported. Like kuru, the illness was dominated by cerebellar signs and relatively little mental deterioration. The diagnosis was strongly supported premortem by the presence of two abnormal 30 kDa proteins in the CSF that are seen almost exclusively in CJD. The characteristic clinical picture coupled with such biochemical data allow a reasonably accurate premortem diagnosis of hGH-related iatrogenic CJD to be made.
IN Der vierte amerikanische, histologisch bestätigte Creutzfeldt-Jakob-Fall mit einer Wachstumshormonvorgeschichte war charakterisiert durch Kleinhirnausfälle bei relativ geringen mentalen Verlusten. Die Diagnose wurde bereits premortal aufgrund der Anwesenheit zweier abnormer 30 kDa Proteine in der Rückenmarksflüssigkeit gestellt.
MH Adult; Brain/*pathology; Case Report; Cerebral Cortex/pathology; Cerebrospinal Fluid Proteins/analysis; Creutzfeldt-Jakob Syndrome/*etiology/pathology; Growth Hormone/*adverse effects/therapeutic use; Human; Hypopituitarism/*drug therapy; Male
AD Department of Neurology, Geisinger Medical Center, Danville, PA 17822.
SP englisch
PO USA