NR AIEO
AU McHattie,S.; Wells,G.A.H.; Bee,J.; Edington,N.
TI Clusterin in bovine spongiform encephalopathy (BSE)
QU Journal of Comparative Pathology 1999 Aug; 121(2): 159-71
PT journal article
AB Clusterin mRNA, detected in increased quantities in the cervical spinal cord of cattle with bovine spongiform encephalopathy (BSE), was localized mainly in the neuroglia (including astrocytes) of the lateral and ventral areas of white matter. Axonal degeneration was also observed in these areas. The dorsal horns of the spinal cord in which BSE prion protein (PrP(BSE)) was deposited did not exhibit strong clusterin "up-regulation" but showed increased clusterin immunolabelling with a punctate distribution in the neuropil. Labelling of adjacent sections of the grey matter in BSE-affected spinal cord and thalamus demonstrated that the clusterin was deposited in association with extracellular PrP(BSE).
MH Animal; Blotting, Northern; Cattle; Cell Count; Central Nervous System/*metabolism/pathology; Encephalopathy, Bovine Spongiform/*metabolism/pathology; Glycoproteins/*metabolism; Immunohistochemistry; In Situ Hybridization; Nerve Tissue Proteins/metabolism; Neuropil/metabolism; Prions/metabolism; RNA, Messenger/metabolism; Spinal Cord/metabolism/pathology; Support, Non-U.S. Gov't; Thalamus/metabolism
AD The Royal Veterinary College, London, NW1 OTU, UK
SP englisch
PO England