NR AIEX
AU McKenzie,D.; Kaczkowski,J.; Marsh,R.F.; Aiken,J.M.
TI Amphotericin B delays both scrapie agent replication and PrPres accumulation early in infection
QU Journal of Virology 1994 Nov; 68(11): 7534-6
PT journal article
AB Amphotericin B delays the onset of clinical symptoms in hamsters infected with scrapie agent strain 263K. Here we show that accumulation of a scrapie-specific isoform of the prion protein (PrPres) and agent replication were delayed early in amphotericin B-treated animals. By 8 weeks postinfection, only untreated animals exhibited clinical symptoms of scrapie infection whereas PrPres levels and titers were similar in treated and untreated animals. This suggests that although PrPres accumulation and agent replication are linked, they are not the sole factors required for the onset of clinical disease.
IN Amphotericin B verzögert bei scrapieinfizierten Hamstern das Einsetzen der klinischen Symptome, obwohl es keinen Einfluß auf die Menge der infektiösen Prionproteine zu haben scheint.
ZR 19
MH Amphotericin B/*pharmacology; Animal; Brain/virology; Hamsters; Male; Mesocricetus; PrPsc Proteins/*drug effects/*metabolism; Scrapie/metabolism/*microbiology; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S.; Virus Replication/*drug effects
AD Department of Animal Health and Biomedical Sciences, University of Wisconsin-Madison 53706.
SP englisch
PO USA