NR AIFG
AU McKinley,M.P.; Hay,B.; Lingappa,V.R.; Lieberburg,I.; Prusiner,S.B.
TI Developmental expression of prion protein gene in brain
QU Developmental Biology 1987 May; 121(1): 105-10
PT journal article
AB Synthesis of the cellular isoform of the prion protein (PrPc) was found to be regulated during development of the hamster brain. PrP poly A(+) RNA was readily detectable 10 days postpartum; after 20 days of age, no change in its level could be detected through 13 months of age. Low levels of PrP poly A(+) RNA were detectable 1 day after birth. By contrast, myelin basic protein poly A(+) RNA was found at high levels in brain at 30 days of age and thereafter declined steadily. Using monospecific PrP antisera, immunoprecipitable cell-free translation products were detected at low levels 2 days after birth and increased progressively through 10 days of age. How the levels of PrP mRNA participate in brain development and function remains to be established.
MH Animal; Brain/growth & development/*physiology; Gene Expression Regulation; Hamsters; *Prions; RNA, Messenger/genetics; Sialoglycoproteins/*genetics; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S.
SP englisch
PO USA