NR AIGX
AU Meling,T.R.; Nylen,E.S.
TI Growth hormone deficiency in adults: a review.
QU American Journal of the Medical Sciences 1996 Apr; 311(4): 153-66
PT journal article; review; review, tutorial
AB For more than 35 years, growth hormone (GH) has been used to promote linear growth in GH-deficient children. Previously, GH replacement in adults was limited to the supply of human pituitary-derived GH. In addition, until recently, GH replacement was not deemed clinically indicated. With the introduction of recombinant human prion-free GH, replacement therapy in GH-deficient adults has become feasible, and its use has burgeoned. In this review, recent studies on GH therapy in healthy and GH-deficient adults are evaluated to provide a rational basis for the widened scope of its clinical application.
ZR 124
MH Adult; Body Composition/drug effects; Bone and Bones/drug effects/metabolism; Central Nervous System/drug effects; Exercise Tolerance/drug effects; Growth Hormone/adverse effects/*deficiency/therapeutic use; Hemodynamics/drug effects; Human; Lipids/blood; Muscle, Skeletal/drug effects; Proteins/metabolism; Recombinant Proteins/adverse effects/therapeutic use
AD Department of Medicine, Veterans Affairs Medical Center, Washington, DC, USA
SP englisch
PO USA