NR AIHC
AU Mendez,M.F.; Selwood,A.; Frey,W.H.2nd
TI Clinical characteristics of chronic Creutzfeldt-Jakob disease
QU Journal of Geriatric Psychiatry and Neurology 1994 Oct-Dec; 7(4): 206-8
PT journal article
AB Chronic Creutzfeldt-Jakob disease, presenting in later life, may be difficult to distinguish from other dementing illnesses. Patients with this disease may lack the characteristic myoclonus and electroencephalographic complexes. We report four patients with a slowly progressive dementia who were misdiagnosed during life and had a spongiform encephalopathy at autopsy. All four patients had early extrapyramidal rigidity, primitive reflexes, and other neurologic signs. The presence of these neurologic findings early in the course of a dementia suggests that clinicians should consider chronic Creutzfeldt-Jakob disease, evaluate the patient with electroencephalographic studies, and emphasize universal tissue precautions.
MH Aged; Basal Ganglia Diseases/etiology/physiopathology; Case Report; Cerebral Cortex/*physiopathology/ultrastructure; Chronic Disease; Creutzfeldt-Jakob Syndrome/complications/*diagnosis/physiopathology; Dementia/diagnosis; Diagnosis, Differential; Female; Human; Lewy Bodies/ultrastructure; Male; Middle Age; Personality Disorders/etiology; Support, Non-U.S. Gov't
AD Department of Neurology, St. Paul-Ramsey Medical Center, St. Paul Minnesota 55101.
SP englisch
PO USA