NR AIMA
AU Mizusawa,H.; Hirano,A.; Llena,J.F.
TI Involvement of hippocampus in Creutzfeldt-Jakob disease
QU Journal of the Neurological Sciences 1987 Dec; 82(1-3): 13-26
PT journal article
AB The hippocampus is generally believed to be only rarely affected in Creutzfeldt-Jakob disease. In a systematic study of the hippocampus in 6 cases of Creutzfeldt-Jakob disease, the stratum moleculare-lacunosum showed a definite spongiform change with gliosis in 5 cases. The stratum radiatum et pyramidale showed spongiform change in 3 of the 5 cases. The subiculum, presubiculum, parasubiculum and entorhinal cortex were involved in all the cases. These results suggest that involvement of the hippocampus may not be uncommon in Creutzfeldt-Jakob disease. The stratum moleculare-lacunosum seems to be the site preferentially affected. This pathology may contribute to progression of dementia in Creutzfeldt-Jakob disease.
MH Adult; Aged; Creutzfeldt-Jakob Syndrome/*pathology; Female; Hippocampus/*pathology; Human; Male; Middle Age
AD Department of Pathology, Montefiore Medical Center, Bronx, NY 10467.
SP englisch
PO Niederlande