NR AIMY
AU Moll,S.; White,G.C.2nd
TI Treatment of the hemophilias
QU Current Opinion in Hematology 1995 Sep; 2(5): 386-94
PT journal article; review; review, tutorial
AB The treatment of hemophilia and conditions that frequently afflict hemophilic patients, such as arthropathy, HIV infection, and viral hepatitis, are discussed. Long-term prophylaxis with Factor VIII or IX is very successful at preventing disabling arthropathy. Much research is being done on gene therapy and prolonged periods of Factor VIII and IX expression have already been achieved in animals. In HIV-seropositive hemophilic patients the CD4 count appears to decline more slowly in patients treated with higher purity than with lower-purity products. Thermoresistant non-lipid-enveloped viruses, such as parvovirus, do not become inactivated by the currently used virucidal methods.
ZR 65
MH Blood Coagulation Factors/therapeutic use; Blood Transfusion/adverse effects; Creutzfeldt-Jakob Syndrome/transmission; Gene Therapy; Hemophilia A/*therapy; Hemorrhage/prevention & control; Hepatitis, Viral, Human/transmission; Human; Virus Diseases/transmission
AD University of North Carolina, Chapel Hill, USA
SP englisch
PO USA