NR AINW
AU Mora,C.A.; Garruto,R.M.; Brown,P.; Guiroy,D.; Morgan,O.S.; Rodgers-Johnson,P.; Ceroni,M.; Yanagihara,R.; Goldfarb,L.G.; Gibbs,C.J.Jr.; et al.
TI Seroprevalence of antibodies to HTLV-I in patients with chronic neurological disorders other than tropical spastic paraparesis
QU Annals of Neurology 1988; 23 Suppl: S192-5
PT journal article
AB Human T-lymphotropic virus type I (HTLV-I), the etiological agent of adult T-cell leukemia/lymphoma, also appears to be the cause of tropical spastic paraparesis, a chronic myelopathy reported in several different regions of the world. The prevalence of antibodies to HTLV-I in patients with chronic neurodegenerative disorders other than tropical spastic paraparesis and in patients with some muscle inflammatory disorders has been investigated. IgG antibodies to HTLV-I were measured in the sera and/or cerebrospinal fluid from 82 Guamanian patients with amyotrophic lateral sclerosis and parkinsonism-dementia, 164 Guamanian normal controls, 10 patients with kuru from the Eastern Highlands of Papua New Guinea, 4 patients with Viliuisk encephalomyelitis from the Iakut region of eastern Siberia, 45 Italian patients with multiple sclerosis, and 56 patients with polymyositis (49 from the United States and 7 from Jamaica). As determined by enzyme-linked immunosorbent assay, Western immunoblot, and gelatin particle agglutination techniques, serological evidence of HTLV-I infection was found in 1 patient with amyotrophic lateral sclerosis and 1 control subject from Guam, and in 1 patient from the United States and all 7 Jamaican patients with polymyositis. Except for the high seropositivity rate among the group of Jamaican patients with polymyositis, our data indicate that HTLV-I is an unlikely causative agent in the spectrum of the neurological diseases examined. The seropositivity of the 7 Jamaican patients with polymyositis requires further study.
MH Adult; Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis/immunology; Antibodies, Viral/*analysis/chemical synthesis; Chronic Disease; Deltaretrovirus Antibodies; Enzyme-Linked Immunosorbent Assay; Human; Middle Age; Muscle Spasticity/physiopathology; Nervous System Diseases/*immunology; Paraplegia/physiopathology; Parkinson Disease/immunology; Tropical Climate
AD Laboratory of Central Nervous System Studies, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, MD 20892.
SP englisch
PO USA