NR AIRV
AU Nagaoka,U.; Kurita,K.; Hosoya,T.; Kitamoto,T.; Kato,T.
TI [Diffusion images on brain MRI in Creutzfeldt-Jakob disease]
QU Rinsho Shinkeigaku. Clinical Neurology 1999 Apr; 39(4): 468-70
PT journal article
AB We report a 72-year-old man with Creutzfeldt-Jakob disease. He showed a progressive dementia, myoclonus, and other neurological symptoms. DNA analysis showed a normal variation of prion gene (codon 129, Met/Met: codon 219, Glu/Glu). He had periodic synchronous discharge on electroencephalogram and brain atrophy on CT scan and MRI. Diffusion images on his brain MRI revealed a marked increase in signal intensity in the caudate nuclei, putamen, and cerebral cortices. These changes may represent spongy changes of the brain and seem to be a feature of brain MRI in Creutzfeldt-Jakob disease.
MH Aged; Atrophy; Brain/*pathology; Case Report; Creutzfeldt-Jakob Syndrome/diagnosis/*pathology; English Abstract; Human; Image Enhancement; *Magnetic Resonance Imaging; Male; Prions/genetics
AD Third Department of Internal Medicine, Yamagata University School of Medicine, Japan.
SP japanisch
PO Japan