NR AISV
AU Nakazato,Y.; Hirato,J.; Ishida,Y.; Hoshi,S.; Hasegawa,M.; Fukuda,T.
TI Swollen cortical neurons in Creutzfeldt-Jakob disease contain a phosphorylated neurofilament epitope
QU Journal of Neuropathology and Experimental Neurology 1990 May; 49(3): 197-205
PT journal article
AB The distribution of swollen neurons and the presence of a phosphorylated neurofilament protein (NFP) epitope in these cells were studied in six cases of Creutzfeldt-Jakob disease (CJD). Swollen neurons are widely distributed in the cerebral cortex and are most abundant in the cingulate and parahippocampal gyri. They are more numerous in the panencephalopathic type of CJD than in the subacute spongiform encephalopathic type. A phosphorylated epitope of NFP was detected in the perikarya of swollen neurons by an immunocytochemical method using a series of monoclonal antibodies that distinguish phosphorylated and nonphosphorylated epitopes of NFP. This abnormal distribution of phosphorylated NFP epitopes indicates that the process of NFP phosphorylation is altered in neurons affected by CJD. This investigation, in accordance with previous studies, suggests that the abnormal post-translational modification of the neurofilament may play an important role in the pathogenesis of several neurodegenerative disorders.
IN Überall in den Hirnrinden von 6 Creutzfeldt-Jakob-Patienten wurden geschwollene Neuronen beobachtet, deren Perikarya eine phosphorylierte Form eines Neurofilamentproteins enthielten.
MH Antibodies, Monoclonal/diagnostic use; Cerebral Cortex/*immunology/pathology; Creutzfeldt-Jakob Syndrome/*immunology/pathology; Cytoskeleton/*immunology; *Epitopes; Human; Immunohistochemistry; Intermediate Filaments/*immunology; Neurons/*immunology; Phosphorylation
AD Department of Pathology, Gunma University School of Medicine, Japan.
SP englisch
PO USA