NR AITJ
AU Narang,H.K.
TI Origin and implications of bovine spongiform encephalopathy
QU Proceedings of the Society for Experimental Biology and Medicine 1996 Apr; 211(4): 306-22
PT journal article; review; review, tutorial
AB All spongiform encephalopathies in animals, including humans, are slow developing infectious diseases. The current working theory links the origin of bovine spongiform encephalopathy (BSE) to the feeding of cattle with meat and bone meal prepared from scrapie-infected sheep remains. Recycling of cattle meat and bones (MBM) essentially resulted in the selection of a single strain from the "wild type", a mixture of 20 strains. The BSE agent is easily transmitted through ingestion, with some evidence of vertical transmission. Paradoxically, cattle have selected a major new strain which appears to be more virulent than an unselected strain found in scrapie sheep. The same strain of BSE agent is implicated in the occurrence of spongiform encephalopathy in domestic cats, tiger, and some exotic species of ruminants in zoos. The properties of BSE and its spread into cattle are still disputed. Since our understanding of the disease and its transmissibility in humans must await observations that will be made over some years to come, it is important to keep a reasonable perspective and ensure that any speculative comment is consistent with fact. In risk assessment in such circumstances, it is tempting give too much credence to persuasive parallels when direct relevant information is not available. On the other hand, it would also not be wise to assume that the disease will die by itself and will have no effect on humans.
IN Harash Narang behauptet dreist, der natürliche Scrapie-Erreger bestehe aus einer Mischung von 20 Stämmen. Diese Behauptung ist absolut unwissenschaftlich, denn es gibt für sie nicht nur keinen Beweis, sondern nicht einmal Hinweise. Die mehrfache Passage dieses ursprünglichen Scrapie-Errergemisches durch die Tiermehlproduktion, das Verfüttern an Rinder und die erneute Tiermehlproduktion habe einen einzigen, virulenteren Erregertyp herausselektioniert. Nichts spricht dafür, dass der BSE-Erreger virulenter als der Scrapie-Erreger ist und wer hat die Zahl der BSE-Erregerstämme ermittelt? Bezüglich der Übertragbarkeit auf Menschen spricht der Autor in Rätseln und sagt nichts substanzielles.
ZR 105
MH Animal; Cerebral Cortex/pathology/ultrastructure; *Encephalopathy, Bovine Spongiform/epidemiology/etiology/pathology; Great Britain/epidemiology; Scrapie/epidemiology/transmission; Support, Non-U.S. Gov't
AD Ken Bell International, Newcastle upon Tyne, United Kingdom.
SP englisch
PO USA