NR AITS
AU Narang,H.K.
TI Scrapie-associated tubulofilamentous particles in scrapie hamsters
QU Intervirology 1992; 34(2): 105-11
PT journal article
AB Examination of thin sections from the cerebral cortex of scrapie-infected hamster brains revealed characteristic circular 26-30 nm diameter tubulofilamentous particles, identical to those previously described in both experimentally induced scrapie in mice, hamsters and natural scrapie of sheep, bovine spongiform encephalopathy and human Creutzfeldt-Jakob disease and mice and chimpanzees infected with Creutzfeldt-Jakob disease. Longitudinal forms of tubulofilamentous particles were also observed in dendrites and myelinated axons. Both transverse and longitudinally cut particles were readily distinguished from microtubules and synaptic vesicles, thus there appears to be no relationship between tubulofilamentous particles, and microtubules or synaptic vesicles.
IN Der Autor führt viele zu prüfende Argumente gegen die Priontheorie an und meint, der Entzug von Prionprotein könnte die Zellmembran destabilisieren.
MH Animal; Cerebral Cortex/ultrastructure; DNA, Mitochondrial/ultrastructure; DNA, Single-Stranded/ultrastructure; Female; Hamsters; Inclusion Bodies/ultrastructure; Mesocricetus; Microscopy, Electron; Microtubules/ultrastructure; Models, Molecular; Prions/*ultrastructure; Scrapie/*pathology; Synaptic Vesicles/ultrastructure; Vacuoles/ultrastructure
AD Public Health Laboratory, Newcastle General Hospital, Newcastle-upon-Tyne, UK
SP englisch
PO Schweiz
OR Prion-Krankheiten 6