NR AIXA
AU Nishida,Y.; Nishino,S.
TI Contribution of a metal-peroxide adduct to neurodegeneration is due to its oxidative protease activity
QU Zeitschrift für Naturforschung. Section C. Journal of Biosciences 1999 Dec; 54(12): 1107-14
PT journal article; review; review, tutorial
AB Many hypotheses have been developed to explain aging and age-related neurodegenerative disorders; one of the most compelling is the role of oxidative stress to induce changes in protease activity in brains of patients of Alzheimer's disease and prion disease. At the moment however, there is no clear answer how protein degradation may be achieved in the brain. We have observed that several metal compounds can degrade proteins in the presence of hydrogen peroxide, and elucidated the reaction scheme based on the new theoretical point for the reactivity of a metal-peroxide adduct with eta 1-coordination mode. In this article we would like to point out the importance of a copper(II)-peroxide adduct to promote neurodegenerative diseases such as prion disease and amyotrophic lateral sclerosis through its oxidative protease function.
ZR 41
MH *Aging; Amyloid beta-Protein Precursor/chemistry/*metabolism; Animal; Base Sequence; Endopeptidases/*metabolism; Human; Metals/chemistry/*metabolism; Molecular Sequence Data; Nerve Degeneration/enzymology/*metabolism; Peroxides/chemistry/*metabolism
AD Institute for Molecular Science, Okazaki, Japan. yuzo@ims.ac.jp
SP englisch
PO Deutschland