NR AIYJ
AU Nyberg,P.; Almay,B.G.; Carlsson,A.; Masters,C.; Winblad,B.
TI Brain monoamine abnormalities in the two types of Creutzfeldt-Jakob disease
QU Acta Neurologica Scandinavica 1982 Jul; 66(1): 16-24
PT journal article
AB Analysis of monoamine concentrations in brain tissue was carried out on the two types of Creutzfeldt-Jakob disease (CJD). The results showed decreased levels of catecholamines compared to control cases in a number of areas, and the reductions were most pronounced for dopamine. In general, the case classified as the amyotrophic form of CJD showed a greater degree of a monoamine loss than the case with spongiform encephalopathy, which is the typical transmissible form of CJD. These findings support the scarce available data indicating disturbances in the catecholaminergic systems in these types of brain diseases, and may have therapeutic implications.
IN Die Untersuchung von 2 Creutzfeldt-Jakob-Patienten ergab eine Reduktion von Catecholaminkonzentrationen in verschiedenen Hirnarealen. Am stärksten ausgeprägt war dieser Effekt bei Dopamin. Bei einem Fall von amyotropher CJD war der Effekt stärker als bei einem als normal bezeichneten Fall.
MH Aged; Brain/pathology; *Brain Chemistry; Case Report; Creutzfeldt-Jakob Syndrome/*metabolism/pathology; Dopamine/*analysis; Female; Human; Hydroxyindoleacetic Acid/*analysis; Male; Middle Age; Norepinephrine/*analysis; Serotonin/*analysis; Support, Non-U.S. Gov't; Tissue Distribution
SP englisch
PO Dänemark