NR AJCG
AU Otto,M.; Esselmann,H.; Schulz-Schaeffer,W.J.; Neumann,M.; Schröter,A.; Ratzka,P.; Cepek,L.; Zerr,I.; Steinacker,P.; Windl,O.; Kornhuber,J.; Kretzschmar,H.A.; Poser,S.; Wiltfang,J.
TI Decreased beta-amyloid1-42 in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease
QU Neurology 2000 Mar 14; 54(5): 1099-102
PT journal article
AB OBJECTIVES: Decreased levels of Abeta1-42 are found in CSF of patients with AD. Because early stages of Creutzfeldt-Jakob disease (CJD) and AD share several clinical features, we investigated Abeta1-42 levels in CSF of these groups, inferring that this might give additional help in differentiating patients with CJD from AD patients. METHODS: We investigated 27 patients with CJD, 14 patients with AD, 19 patients with other dementias, and 20 nondemented controls (NDC) for Abeta1-42 in CSF. Twenty-four of the 27 CJD patients were neuropathologically verified. All the neuropathologically verified patients presented with a type 1 prion protein pattern. CJD patients were all homozygous for methionine at codon 129. Except in five CJD patients, no beta-amyloid plaques were seen. Additionally, APOE status was determined in patients with CJD. RESULTS: Levels of Abeta1-42 in CSF were decreased in patients with AD as well as in CJD. Levels of Abeta1-42 in CSF of patients with CJD and AD were significantly different from the other dementia and NDC groups. There was no substantial difference between the CJD and AD groups (p = 0.66). Decreased levels of Abeta1-42 did not correlate with the APOE epsilon4 load in patients with CJD. CONCLUSION: Low levels of Abeta1-42 in CSF do not exclude a diagnosis of CJD. Decreased levels of Abeta1-42 in CSF can occur without beta-amyloid plaque formation in the brain. However, the underlying mechanism of this phenomenon must be elucidated.
MH Adult; Aged; Aged, 80 and over; Amyloid beta-Protein/*cerebrospinal fluid; Creutzfeldt-Jakob Syndrome/*cerebrospinal fluid; Enzyme-Linked Immunosorbent Assay; Female; Human; Immunoblotting; Male; Middle Age; Support, Non-U.S. Gov't
AD Neurologische Klinik und Poliklinik, Georg-August-Universität Göttingen, Germany. motto@gwdg.de
SP englisch
PO USA