NR AJCK
AU Otto,M.; Wiltfang,J.; Tumani,H.; Zerr,I.; Lantsch,M.; Kornhuber,J.; Weber,T.; Kretzschmar,H.A.; Poser,S.
TI Elevated levels of tau-protein in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease
QU Neuroscience Letters 1997 Apr 11; 225(3): 210-2
PT journal article
AB Creutzfeldt-Jakob disease (CJD) is a rare, fatal, neurodegenerative disease caused by a transmissible agent designated as proteinaceous infectious agent (prion). Searching for biochemical markers of CJD, we analysed cerebrospinal fluid (CSF) samples of 53 patients for tau-protein using an enzyme linked immunoassay (ELISA). In a group of 21 patients with definite CJD seen in the German case control study for CJD, tau-protein concentrations in CSF were significantly higher than in two control-groups of patients with other diseases (median 13,153 pg/ml, range 1,533-27,648 pg/ml; P = 0.0001). One group comprised 19 patients who were seen in the same study and were diagnosed as having other dementing diseases (tau concentration: median 558 pg/ml, range 233-1,769 pg/ml). The second control group comprised 13 patients from our hospital with no dementing disease (tau concentration: median 296 pg/ml, range 109-640 pg/ml). We conclude that determination of tau protein levels in CSF is a useful marker for laboratory diagnosis of CJD.
MH Aged; Aged, 80 and over; Creutzfeldt-Jakob Syndrome/*metabolism; Female; Human; Male; Middle Age; Support, Non-U.S. Gov't; tau Proteins/*cerebrospinal fluid
AD Department of Neurology, Georg-August-University Göttingen, Germany. 100634.133@compuserve.com
SP englisch
PO Irland