NR AJKW
AU Picard-Hagen,N.; Gayrard,V.; Laroute,V.; Grandjean,C.; Andreoletti,O.; Elsen,J.M.; Schelcher,F.; Toutain,P.L.
TI Discriminant value of blood and urinary corticoids for the diagnosis of scrapie in live sheep
QU The Veterinary Record 2002 Jun 1; 150(22): 680-4
PT evaluation studies; journal article
AB The mean (sd) concentration of plasma 20beta-dihydrocortisol in 126 scrapie-affected sheep was 5-5 (7.0) ng/ml compared with 1.1 (0.7) ng/ml in 52 healthy sheep. The mean (sd) concentration of creatinine in the urine of 93 scrapie-affected sheep was 2.43 (1.56) microg/ml compared with 0.94 (0.86) pg/ml in 49 healthy sheep and 1.10 (0-95) pg/ml in 25 sheep with other diseases. These discriminant analyses carried out on healthy and scrapie-affected sheep showed that plasma 20beta-dihydrocortisol and urinary creatinine were the best predictors of the disease, and classified correctly 98 per cent of healthy sheep and 82 per cent of scrapie-affected sheep.
MH Animal; Biological Markers/blood/urine; Case-Control Studies; Creatinine/*urine; Female; Hematologic Tests/standards/veterinary; Hydrocortisone/*analogs & derivatives/*blood; Male; Predictive Value of Tests; Pregnancy; Scrapie/blood/*diagnosis/urine; Sheep; Support, Non-U.S. Gov't; Urinalysis/standards/veterinary
AD Unite Mixte de Recherche, INRA-ENVT 181, Ecole Nationale Veterinaire de Toulouse, France.
SP englisch
PO England