NR AJLF
AU Piccardo,P.
TI Amyloidoses of the nervous system in the transmissible dementias
QU Archives of Medical Research 1992 Spring; 23(1): 3-6
PT journal article; review; review, tutorial
AB The transmissible spongiform encephalopathies, both in humans and in animals, are neurodegenerative diseases which do not evoke an immune response in the host. The search for the etiological agent has led to the prion hypothesis, which proposes that a host-encoded protein may be the causal agent itself or a part of it. In humans, a low percentage of these transmissible encephalopathies are familial. Investigations centered on the understanding of the pathogenesis of the transmissible spongiform encephalopathies have implications, not only in basic sciences, but in clinical medicine as well.
ZR 41
MH *Amyloidosis/genetics/microbiology/pathology/veterinary; Animal; Hamsters; Human; Mammals/genetics; Mice; Mutation; PrPsc Proteins; *Prion Diseases/genetics/microbiology/pathology/veterinary; Prions/analysis/genetics/pathogenicity; Species Specificity; Support, Non-U.S. Gov't
AD Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada.
SP englisch
PO Mexiko