NR AJMB
AU Plazzi,G.; Schutz,Y.; Cortelli,P.; Provini,F.; Avoni,P.; Heikkila,E.; Tinuper,P.; Solieri,L.; Lugaresi,E.; Montagna,P.
TI Motor overactivity and loss of motor circadian rhythm in fatal familial insomnia: an actigraphic study.
QU Sleep 1997 Sep; 20(9): 739-42
PT journal article
AB The 24-hour rest-activity pattern and the amount of motor activity was studied in a patient with fatal familial insomnia (FFI) by means of wrist actigraphy. During the study, the patient underwent indirect calorimetry. The 52-day recording showed severe disruption of the 24-hour rest-activity pattern with increased motor activity up to 80%. The 24-hour energy expenditure, assayed in a respiration chamber, was strikingly elevated by 60%. Chronic motor overactivity and loss of circadian rest-activity rhythm may play a role in the progressive metabolic exhaustion leading to death in FFI patients.
MH Body Mass Index; Calorimetry, Indirect; Case Report; *Circadian Rhythm; Comparative Study; Energy Intake; Fatal Outcome; Human; Hyperkinesis/*etiology; Male; Middle Age; Sleep Initiation and Maintenance; Disorders/complications/diagnosis/*genetics
AD Institute of Neurology, University of Bologna, Italy.
SP englisch
PO USA