NR AJMJ
AU Pocchiari,M.; Salvatore,M.; Ladogana,A.; Ingrosso,L.; Xi,Y.G.; Cibati,M.; Masullo,C.
TI Experimental drug treatment of scrapie: a pathogenetic basis for rationale therapeutics.
QU European Journal of Epidemiology 1991 Sep; 7(5): 556-61
PT journal article; review; review, tutorial
AB Pharmacological treatment with polyanions or amphotericin B in hamsters with experimental scrapie reveals that it is possible to delay the appearance of the disease only when the drug is given before the invasion of the agent into the clinical target areas of the brain. We suggest such early treatment may be possible for individuals at high risk of acquiring the disease, such as healthy mutation-positive relatives of patients with familial Creutzfeldt-Jakob disease or Gerstmann-Sträussler syndrome, or recipients of potentially contaminated pituitary-extracted human growth hormone.
ZR 38
MH Amphotericin B/*therapeutic use; Animal; Brain/drug effects/microbiology; Hamsters; Polymers/*therapeutic use; Prions/drug effects; Scrapie/*drug therapy; Support, Non-U.S. Gov't; Virus Replication/drug effects
AD M.Pocchiari, Department of Biology, University of Lecce, Lecce, present address: Istituto di Patologia Generale, Università Cattolica del S. Cuore, Largo F. Vito, 1 - 00168 Roma, Italy; M.Salvatore, A.Ladogana, L.Ingrosso, Y.G.Xi, M.Cibati, Institute of General Pathology, Catholic University, Rome, Italy; C.Masullo, Institute of Neurology, Catholic University, Rome, Italy
SP englisch
PO Italien
OR Prion-Krankheiten 6