NR AJMO
AU Pocchiari,M.; Macchi,G.; Peano,S.; Conz,A.
TI Can potential hazard of Creutzfeldt-Jakob disease infectivity be reduced in the production of human growth hormone? Inactivation experiments with the 263K strain of scrapie. Rapid communication.
QU Archives of Virology 1988; 98(1-2): 131-5
PT journal article
AB Scrapie infectivity is reduced 5-6 logs following filtration through 100,000 MW cut-off filter plus overnight treatment with 6 M urea. These steps, applied to purified human Growth Hormone (hGH), increase the margin of safety of hGH.
MH Animal; Creutzfeldt-Jakob Syndrome/*prevention & control; Female; Filtration; Growth Hormone/*isolation & purification; Hamsters; Scrapie/*prevention & control; Sodium Hydroxide; Urea
AD Istituto di Neurologia, Universita Cattolica S. Cuore, Rome, Italy.
SP englisch
PO Österreich