NR AJMW
AU Poleshchuk,N.N.; Kapitulets,S.P.; Kapitulets,N.N.; Kvacheva,E.B.; Eremin,V.F.; Votiakov,V.P.
TI [The infectiousness of 18- to 20-kd proteins isolated from the brain of people who have died from amyotrophic leukospongiosis]
OT Infektsionnost' belkov 18-20 kd, vydelennykh iz mozga liudei, umershikh ot amiotroficheskogo leikospongioza
QU Biulleten Eksperimentalnoi Biologii I Meditsiny 1993 Oct; 116(10): 409-12
PT journal article
AB Specific globular structures, 10-12 nm in diameter, having a high resistance to various physicochemical factors and infectivity have been isolated for the first time from the brain of 2 patients, who died of amyotrophic leukospongiosis (AL). It has been shown that these globules contain infectious major protease-resistant protein with a molecular weight of about 18-20 kD. The findings indicate the unique nature of a disease and they open new aspects of AL etiopathogenesis.
MH Animal; Brain Diseases/etiology/*microbiology; Cerebral Cortex/*microbiology; Comparative Study; Cytopathogenic Effect, Viral; Electrophoresis, Polyacrylamide Gel; English Abstract; Guinea Pigs; Human; Microscopy, Electron; Molecular Weight; Prion Diseases/etiology/*microbiology; Prions/analysis/isolation & purification/*pathogenicity/ultrastructure; Serial Passage; Slow Virus Diseases/etiology/*microbiology; Tissue Culture
SP russisch
PO Russland