NR AJMY
AU Poleshchuk,N.N.; Votiakov,V.I.; Il'kevich,Y.G.; Dubovskaia,G.P.; Kolomiets,N.D.
TI [Mechanism of accumulation of prion amyloid in the CNS in experimental amyotrophic leukospongiosis]
OT K mekhanizmu nakopleniia prionovogo amiloida v TsNS pri eksperimental'nom amiotroficheskom leikospongioze
QU Biulleten Eksperimentalnoi Biologii I Meditsiny 1991 Dec; 112(12): 640-3
PT journal article
AB The mechanism of accumulation of prion amyloid in guinea pig CNS in experimental slow virus disease - amyotrophic leuco-spongiosis (AL) was studied. The complex histochemical, immuno-cytochemical and ultrastructural studies revealed specific amyloid deposits in a few brain capillaries and in most of pia matter vessels. Taking into account the high AL agent titer in spleen throughout the disease period, conclusion was drawn of entering AL agent in CNS through blood-liquor barrier and blood-brain barrier. It was supposed that primary immune system damaging took place in AL pathogenesis.
MH Amyloid/*metabolism; Animal; Brain/*metabolism/microbiology/ultrastructure; Brain Diseases/*metabolism/microbiology; Comparative Study; English Abstract; Guinea Pigs; Histocytochemistry; Immunohistochemistry; Pia Mater/*metabolism/microbiology/ultrastructure; *Prions; Slow Virus Diseases/*metabolism/microbiology
SP russisch
PO Russland