NR AJPA
AU Price,D.L.; Borchelt,D.R.; Sisodia,S.S.
TI Alzheimer disease and the prion disorders amyloid beta-protein and prion protein amyloidoses
QU Proceedings of the National Academy of Sciences of the United States of America 1993 Jul 15; 90(14): 6381-4
ER Proc Natl Acad Sci U S A 1993 Oct 1;90(19):9233
PT journal article; review; review, academic
AB Alzheimer disease and the prion disorders/spongiform encephalopathies share many common features. These chronic, progressive, sometimes familial diseases of the central nervous system are characterized by the presence of different types of amyloid deposits in the brain. This review provides a perspective on these two types of neurodegenerative disorders.
ZR 99
MH *Alzheimer Disease/genetics/metabolism/pathology; Amyloid beta-Protein/*metabolism; Amyloidosis/*pathology; Comparative Study; Human; PrPsc Proteins; *Prion Diseases/genetics/metabolism/pathology; Prions/*metabolism; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S.
AD Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205-2196.
SP englisch
PO USA