NR AJRC
AU Prusiner,S.B.
TI Transgenetics and cell biology of prion diseases: investigations of PrPsc synthesis and diversity.
QU British Medical Bulletin 1993 Oct; 49(4): 873-912
PT journal article; review; review, academic
AB Studies with Tg mice have contributed a wealth of new knowledge about the synthesis of prion particles and the pathogenesis of both the genetic and infectious forms of the prion diseases. Transgenetic studies argue persuasively that the 'species barrier' is due to differences in PrP gene sequences among mammals.
ZR 125
MH Animal; Brain/pathology; Genes, Viral; Hamsters; Mice; Mice, Transgenic; Prion Diseases/*genetics/pathology; Prions/biosynthesis/*genetics; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S.
AD Department of Neurology, University of California, San Francisco.
SP englisch
PO England