NR AJSG
AU Prusiner,S.B.; Cochran,S.P.; Alpers,M.P.
TI Transmission of scrapie in hamsters
QU Journal of Infectious Diseases 1985 Nov; 152(5): 971-8
PT journal article
AB Hamsters developed scrapie 100-160 days after eating either scrapie-infected hamsters or infected brain. The clinical signs and neuropathology of scrapie transmitted by cannibalism were identical to those observed after intracerebral or intraperitoneal inoculation of the agent. Oral transmission of scrapie appears to be extremely inefficient. Cannibalism requires a dose of the scrapie agent of approximately 10(9) times greater than that needed to produce the disease by intracerebral injection for comparable periods of incubation. These results provide compelling evidence for oral transmission of scrapie and may offer new insights into the spread of kuru by cannibalism among the Fore people and their neighbors. The extreme inefficiency of oral infection with scrapie might also have implications for understanding the sporadic occurrence and worldwide distribution of Creutzfeldt-Jakob disease.
IN Goldhamster entwickelten Scrapie, 100-160 Tage nachdem sie infizierte Goldhamster oder deren Gehirne gegessen hatten. Die Folgen einer kannibalischen Ansteckung scheinen identisch mit einer Übertragung durch Injektionen zu sein, aber die für eine orale Infektion mit vergleichbarer Inkubationszeit erforderliche Dosis soll um den Faktor 1 Milliarde größer als bei einer intrazerebralen Inokulation gewesen sein.
MH Animal; Brain/microbiology/pathology; *Cannibalism; Female; Hamsters; Male; Mesocricetus; Prions/growth & development; Scrapie/microbiology/pathology/*transmission; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S.; Time Factors
AD Department of Neurology and Biochemistry and Biophysics, University of California, San Francisco 94143, California
SP englisch
PO USA
OR Prion-Krankheiten 6