NR AJSH
AU Prusiner,S.B.; Barry,R.A.; McKinley,M.P.; Bellinger,C.G.; Meyer,R.K.; DeArmond,S.J.; Kingsbury,D.T.
TI Scrapie and Creutzfeldt-Jakob disease prions
QU Microbiological Sciences 1985; 2(2): 33-9
PT journal article; review; review, tutorial
AB Scrapie and Creutzfeldt-Jakob disease are caused by prions which can be distinguished from both viruses and viroids. Aggregates of prions are ultrastructurally and histochemically identical to amyloid. Extracellular collections of prions form amyloid plaques within scrapie-infected brain. Prion amyloid plaques seem analogous to viral inclusion bodies in that they are composed of causative pathogens and are not merely a consequence of the disease.
ZR 54
MH Animal; Creutzfeldt-Jakob Syndrome/*microbiology; Human; *Prions/genetics/ultrastructure; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S.
AD Department of Neurology and Biochemistry and Biophysics, University of California, San Francisco 94143, California
SP englisch
PO USA